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Kim, M. M. M. M. Bear, J. A. Harmin, M. Laptewicz, K. Barbara-Haley, S. Kuersten, E. Markenscoff-Papadimitriou, D. Kuhl, H. F. Worley, G. E. Greenberg, Widespread transcription at neuronal activity-regulated enhancers, Nature 465 (2010) 182e187. M. E. Williamson, D. Y. Zou, O. K. E. Bernstein, Locusspecific editing of histone modifications at endogenous enhancers, Nat. Biotechnol. 31 (2013) 1133e1136. [99] S. D. Brigham, A. D. Hsu, M. Heidenreich, L. J. A. M. Church, F. Zhang, Optical control of mammalian endogenous transcription and epigenetic states, Nature 500 (2013) 472e476.

Varghese, R. Nagarajan, P. H. C. A. F. R. K. Wilson, DNMT3A mutations in acute myeloid leukemia, N. Engl. J. Med. 363 (2010) 2424e2433. F. Fraga, E. Ballestar, A. Villar-Garea, M. Boix-Chornet, J. Espada, G. Schotta, T. Bonaldi, C. Haydon, S. Ropero, K. G. Iyer, A. Pe´rez-Rosado, E. A. Lopez, A. J. Calasanz, D. A. Piris, N. Ahn, A. Imhof, C. Caldas, T. Jenuwein, M. Esteller, Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer, Nat. Genet. 37 (2005) 391e400.

Ohlsson, Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions, Nat. Genet. 38 (2006) 1341e1347. G. Rivenbark, S. S. Beltran, X. G. D. Strahl, P. Blancafort, Epigenetic reprogramming of cancer cells via targeted DNA methylation, Epigenetics 7 (2012) 350e360. -K. Kim, M. M. M. M. Bear, J. A. Harmin, M. Laptewicz, K. Barbara-Haley, S. Kuersten, E. Markenscoff-Papadimitriou, D. Kuhl, H. F. Worley, G. E. Greenberg, Widespread transcription at neuronal activity-regulated enhancers, Nature 465 (2010) 182e187.

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