By William W. Cohen
This functional consultant offers a succinct therapy of the overall innovations of mobile biology, furnishing the pc scientist with the instruments essential to learn and comprehend present literature within the field.
The booklet explores 3 diverse features of biology: biological structures, experimental methods, and language and nomenclature. After a quick advent to phone biology, the textual content makes a speciality of the foundations at the back of the most-widely used experimental techniques and mechanisms, touching on them to well-understood suggestions in machine technological know-how.
The presentation of the fabric has been ready for the reader’s fast snatch of the subject: reviews on nomenclature and heritage notes may be ascertained at a look, and crucial vocabulary is boldfaced during the textual content for simple identification.
Computer technology researchers, pros and desktop technology scholars will locate this an incomparable source and a very good start line for a extra entire exam of mobilephone biology.
"This concise ebook is a superb creation for laptop scientists to the fascinating revolution lower than approach in molecular biology. It offers lucid, high-level descriptions of the basic molecular mechanisms of existence, and discusses the computational rules concerned. I want this little gem was once to be had whilst i used to be ‘learning the ropes’– it will were my first selection of interpreting material."
--Roni Rosenfeld, Carnegie Mellon University
Read or Download A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land PDF
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Additional info for A Computer Scientist's Guide to Cell Biology: A travelogue from a stranger in a strange land
Every location on the paper to which X sticks corresponds to a protein in M with which X interacts. This technique is called a Western blot. Performing the analogous operations starting with a (one-dimensional) gel containing RNA molecules in order to determine which RNAs hybridize to some DNA molecule X is called a Northern blot. Performing a Northern blot with DNA instead of RNA is called a Southern blot. ) The grandchild of the Northern blot is the infamous gene chip (and/or the closely related microarray), which I will talk about next.
More stages of amplification would produce even steeper response curves. Figure 19. Amplification rates of two biological processes. William W. Cohen 33 In Figure 19, the pathway contains two “amplification” steps: both R* and PDE* affect more than one molecule each. Notice that the number of active transducin and PDE molecules grows linearly over time; however, since each PDE* hydrolyzes a linear number of cGMP molecules per unit time, the number of cGMP hydrolyzed grows quadratically over time.
The usual way of doing this is to use some chemical that breaks up the amino acid sequence in a consistent, predictable way: for example, cyanogen bromide will break proteins after each methionine residue. Separating and sorting the fragments of the protein, using a gel or chromatography, will produce a specific pattern called a peptide map. Assuming that the “sorting” is done according to some function f(z), where z is a fragment, one could formally represent the peptide map for protein P as a function hP(n), in which hP(n) is the number of fragments z in P such that f(z)=n.