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By E. Edward Bittar (Eds.)

The fourth quantity of the ''Advances in Molecular and mobile Biology'' sequence. mobilephone biology is a rapidly-developing self-discipline, bringing jointly many separate organic sciences. The interrelations of mobile constitution and serve as at molecular and subcellular degrees are the important topic of the sequence

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1981). Nucleic Acids Res. 9, 683-698. Jabs. E. , Goble, C. , & Cutting, G. R. (1989). Proc. Natl. Acad. Sci. USA 86, 202-206. Jabs, E. , Tuck-Muller, C. , & Rattner, J. B. (1991). Chromosoma 100,251-261. James, T. , & Elgin. S. C. R. (1986). Mol. Cell Biol. 6, 3862-3872. , Philippsen, P. (1989). Mol. Cell Biol. 9, 5585-5593. Johnstone, S. , Rattner, J. , & Waisman, J. D. (1989). J . Cell Biol. 100, abstract 90A. Jokelainen, P. T. (1967). J. of Ultrastructure Res. 16. 1 9 4 4 . Jones, K. W. (1970).

C. WONG and J. B. RATTNER 30 occur in both sister chromatids or only one of the chromatids during anaphase and there is no correlation between the number of lagging chromatids and the frequency of chromatid splaying. Thus, it appears that in the cells derived from individuals with Roberts syndrome the function of the pairing domain as well as the kinetochore domain can be impaired. The variability in expression of the kinetochore domain defect and its expression in only one chromatid of a chromosome suggests that there may be insufficient production of a kinetochore associated protein necessary for events associated specifically with anaphase A.

M. S. (1985). J. Cell Biol. 100, 1716-1723. Earnshaw, W. , & Rattner, J. B. (1989). A map of the centromere (primary constriction) in vertebrate chromosomes at metaphase. In: Mechanisms of Chromosome Distribution and Aneuploidy (Resnick. M.. & Vig. B.. eds), pp. 3 3 4 2 . Alan Liss. New York. Earnshaw, W. C.. & Rothfield. N. (1985). Chromosoma 91, 313-321. Earnshaw. W. C.. Sullivan, K. , Machlin, P. S . , Cooke, C. , Kaiser. , Pollard. T. , Rothfield. N.. & Cleveland, D. W. (1987). J . Cell Biol.

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